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Archive Number 20020718.4794
Published Date 18-JUL-2002
Subject PRO/AH/EDR> Hantavirus pulmonary syndrome update 2002 - USA (02)


HANTAVIRUS PULMONARY SYNDROME UPDATE 2002 - USA (02)
**************************************************
A ProMED-mail post
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ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

In these updates:
[1] & [2] Wyoming
[3] Nebraska

******
[1]
Date: Sat 13 Jul 2002
From: ProMED-mail <promed@promedmail.org>
Source: Newsday.com, Associated Press report, Sat 13 Jul 2002 [edited]
<http://www.newsday.com/news/nationworld/nation/wire/sns-ap-brf-hantavirus-death0714jul13.story?coll=sns%2Dap%2Dnation%2Dheadlines>


Wyoming: Woman Dies From Hantavirus Infection
---------------------------------------------
CHEYENNE: A blood sample from a 20-year-old woman who died last week has 
tested positive for the rare, rodent-borne hantavirus, officials said on 
Sat 13 Jul 2002. A second sample will be sent to the Centers for Disease 
Control and Prevention in Atlanta early this week for confirmation, said 
Scott Seys, deputy state epidemiologist. State and Natrona County health 
officials were treating the case as confirmed hantavirus and had begun 
investigating possible points of exposure.

This would be the third known human case in Wyoming of hantavirus 
infection, which is contracted by breathing dust or eating food 
contaminated by the dried urine, feces, or saliva of rodents. Symptoms 
include fever, aches, difficulty breathing, and flu-like symptoms; death 
occurs in 37 percent of cases. Hantavirus infection was first diagnosed in 
the United States in 1993 in the Four Corners region of the Southwest, when 
33 people were infected and 17 died. The disease has since been found in 31 
states. In recent months, hantavirus cases have been identified in 
Nebraska, Idaho, Colorado and Utah.

--
ProMED-mail
<promed@promedmail.org>

******
[2]
Date: Sun 14 Jul 2002
From: Richard W. Wilsnack, Ph.D. <rwilsnac@medicine.nodak.edu>
Source: Wyoming Tribune-Eagle, online edition, Sun 14 Jul 2002 [edited]



Wyoming: Early Test Results Confirm Hantavirus Diagnosis
--------------------------------------------------------
CHEYENNE: A 20-year-old Casper woman may have died from a rare rodent-borne 
disease, health department officials say. If preliminary tests were 
correct, it would be the third case of hantavirus in the state's history. 
Both previous cases were fatal.

The Wyoming Department of Health in Cheyenne received word Saturday from 
the Mayo Clinic in Minnesota that initial tests indicate the disease is to 
blame for the 8 Jul 2002 death at Wyoming Medical Center in Casper. Early 
next week a second sample will be sent to the U.S. Centers for Disease 
Control and Prevention in Atlanta for confirmation, and results are 
expected about a week later. "At this point we're treating it as a positive 
for the same reason we sent it to Mayo," deputy state epidemiologist Scott 
Seys said in a prepared statement. "Clinically, it looked like hantavirus 
infection. The symptoms fit the classic presentation."

The disease cannot be spread from one person to another, but other people 
exposed to the [virus] could be contaminated too. Natrona County Health 
officials are investigating where the woman may have come in contact with 
hantavirus. She was helping friends remodel a house, and Casper-Natrona 
County Health Department spokesman Marty Thone said that is the likely 
source of infection. "That was just one thing she was doing, but it will be 
part of our investigation," Thone said, adding that the investigation 
should take about 5 days. The woman first became sick on 5 or 6 Jul 2002, 
was admitted to the hospital soon after and died before tests for 
hantavirus were completed, Thone said. "It was very, very quick," he said. 
"And that's typical for hantavirus."

No other potential cases have been reported in Casper or the state, but 
health officials are still encouraging people to be on alert for the 
disease. "What we're recommending if you work in an area or are going into 
an area where there might be rodent droppings is wear a mask, a simple 
woodworker's mask will do. It's a pretty simple way to protect yourself," 
Thone said. Seys said it often takes 2 to 3 weeks for symptoms to appear, 
although it's been known to take up to 6 weeks, and once symptoms appear, a 
person can die within 24 hours. Mice and rats spread the disease through 
their urine, feces, and saliva. [Different hantaviruses are carried by 
specific rodent hosts. The hantavirus probably responsible for this case is 
_Sin Nombre virus_, which is associated predominantly with the deer mouse 
_Peromyscus maniculatus_. - Mod.CP]. It is estimated that 8 percent of 
Wyoming's rodents may be infected with the virus, which cannot be spread 
via insects, livestock or pets.

Hantavirus pulmonary syndrom has been found in 31 states, including 
Wyoming, with deaths in Freemont County in 1993 and Lincoln County in 1999. 
This year, more cases of the virus have been found across the nation, 
particularly in states bordering Wyoming. Hantavirus has been found in 
Colorado, Western Nebraska, Idaho, and Utah in recent weeks, and health 
officials have said the entire Cowboy State is susceptible to infection. 
Seys said drought conditions in the West could be causing the rodent 
excrement to dry out and become airborne more easily. A mild winter has 
been blamed for an increase in both rodent and insect populations that 
normally are reduced during long spans of below-freezing temperatures.

[Byline: Joanne Bowlby]

--
Richard W. Wilsnack, Ph.D.
Department of Neuroscience
University of North Dakota School of Medicine & Health Sciences
Grand Forks, ND 58202-9037
<rwilsnac@medicine.nodak.edu>

******
[3]
Date: Wed 17 Jul 2002
From: Dennis Leschinsky <dennis.leschinsky@hhss.state.ne.us>
Source: Omaha World Herald online, Wed 17 Jul 2002 [edited]
<http://www.omaha.com/index.php?u_np=0&u_pg=36&u_sid=449595>


Nebraska: Second Case of Hantavirus Pulmonary syndrome
------------------------------------------------------
Nebraska's latest cases of hantavirus occurred within days of one another 
last month, but state health officials do not see a connection or believe 
that the public is at increased risk of exposure to the often-fatal viral 
disorder. "These are not real mystery cases," said Dr. Tom Safranek, 
Nebraska's epidemiologist. Both victims spent considerable time outdoors 
and in places where there would likely be rodents. The viruses that cause 
the disease are found in the droppings or urine of rodents, mostly deer 
mice, and can be spread through the air and inhaled. Hantavirus, first 
identified after a cluster of cases in the southwest United States in 1993, 
is not spread through person-to-person contact. More than 300 cases have 
been confirmed nationally, mostly in western states. The Nebraska cases are 
either the third and fourth or the second and third cases in the state, 
depending on the source of information.

A railroad worker died on 13 Jun 2002 in a Scottsbluff hospital, 2 days 
after feeling ill while on the job at a Union Pacific yard. It is possible 
he contracted the virus while camping earlier in the month in South Dakota, 
but there are rodents around the rail yard in South Morrill as well. The 
30-year-old man from Lyman is the first Nebraskan to die from hantavirus, 
which has been fatal in 37 percent of all cases.

A 41-year-old male resident of Imperial felt flu-like symptoms on 20 Jun 
2002, and was eventually hospitalized in Chase County and transferred for 
more intensive care to Good Samaritan Hospital in Kearney. The patient, a 
feedlot manager, was sedated and breathing with the help of a ventilator 
for several days, but was released from the hospital in fair health on the 
morning of Tue 16 Jul 2002.

Tests conducted by the U.S. Centers for Disease Control and Prevention 
confirmed that both men had hantavirus. Testing by the CDC is still pending 
to confirm that hantavirus caused the death of a woman in Casper, Wyo., on 
Monday. Safranek said the timing of these cases, and the fact that 2 of 
them took place in western Nebraska, does not suggest any relationship. Any 
increased risk for hantavirus will likely be detected by the state through 
its routine testing of deer mice, he said. The latest tests show that 
between 5 percent and 15 percent of deer mice have the virus, which has 
been the norm, he said. "This is a rare disease and it doesn't seem to 
cluster."

Union Pacific ordered tests of mice found at its South Morrill rail yard 
and at the home of one of the cases, but didn't find any carrying 
hantavirus, a spokesman said. The company is nonetheless providing 
information about the disease and prevention tips to its workers. 
Hantavirus is unusual in metro areas, partly because deer mice are far more 
common in rural areas.

A 1999 Nebraska case involved a suburban La Vista resident, although it is 
possible he contracted the disease in a rural area. The 25-year-old man was 
hospitalized for weeks, but eventually recovered. Lab tests conflicted over 
whether he had hantavirus, but Safranek in 2000 said the state was treating 
it as the state's second confirmed case. The state's first confirmed case 
was in 1998 in Benkelman. The CDC, which had negative tests for the La 
Vista man, only lists the state as having one previous case.

[Byline: Jeremy Olson]

--
Dennis Leschinsky
Nebraska Health and Human Services System
Communicable Disease Surveillance
402-471-6450 phone
402-471-3601 fax
<dennis.leschinsky@hhss.state.ne.us>

[Dennis Leschinsky adds the following information: "This second 
case-patient is a 41-year-old male farm worker in Chase County (southwest 
part of Nebraska -  about 175-200 miles from the previous hantavirus 
pulmonary syndrome case-patient this summer). He had been repairing bunk 
lines at the feedlot he manages. This involved tearing up the concrete bunk 
lines with a tractor with a front-end loader. Mice nests were disturbed 
while tearing up the old bunk lines. His onset was 18 Jun 2002 and was 
hospitalized on 22 Jun 2002 and released on 16 Jul 2002. The patient had a 
positive ELISA test at a commercial lab and had confirmatory testing done 
at CDC." Since according to the press report 5-15 percent of deer mice in 
Nebraska are carrying hantavirus, it is likely that the etiologic agent is 
the hantavirus _Sin Nombre virus_. - Mod.CP]

[see also:
Hantavirus pulmonary syndrome - USA (Arizona)      20020607.4429
Hantavirus pulmonary syndrome - USA (Colorado)      20020605.4411
Hantavirus pulmonary syndrome - USA (Nebraska)      20020702.4650
Hantavirus pulmonary syndrome - USA (Texas)      20020512.4180
Hantavirus pulmonary syndrome - USA (Texas) (02) 20020515.4220
Hantavirus pulmonary syndrome - USA (Utah)      20020505.4105
Hantavirus pulmonary syndrome - USA (Utah) (02) 20020508.4135
Hantavirus pulmonary syndrome - USA (Utah) (03) 20020609.4446
Hantavirus pulmonary syndrome - USA (Utah) (04) 20020628.4626
Hantavirus pulmonary syndrome update 2002 - USA (01) 20020630.4641]
.................................mpp/cp/pg/dk



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